Background :
@EN Previous studies have demonstrated that patients with psoriasis may have an increased risk of contacting a variety a variety of noncutaneous diseases, including arterial and venous venous occlusive diseases. Changes in plasma lipid and
lipoprotein
composition in patients with psoriasis may be the reason for the increased risk of atherosclerosis in these patients.
@ES Objective :
@EN This study was carried out to investigate differences of serum lipid, lipoprotein and apolipoprotein levels between the psoriasis patients and control groups and to suggest which are related with atherogenic risk in the psorialsis.
@ES Methods :
@EN Serum lipid, lipoprotein and apolipoprotein levels were measured in 100 patient with pasoriasis and in 30 healthy people.
@ES Results :
@EN In the serum lipids study total cholesterol, TG, LDL-C and VLDL-C levels were lower and HDL-C level was higher in the psoriasis group than in the control group. Statistical signifi cant differences were noticed in total cholesterol levels
between
the female psoriasis patients and the female control groups. In the serum lipoproteins study apolipoprotein B and lipoprotein (a) levels were higher and apolipoprotein A I level was lower in the psoriasis group than in the control group, and
statistical
significant differences of apolipoprotein B and lipoprotein (a) levels were noticed in the atherogenic risk group and severe psoriasis group compared with the control group.
@ES Conclusion :
@EN These findings suggest that the atherogenic risk in psoriasis is relatied with the high level of apolipoproteins especially apolipoprotein B, and is not related with serum lipid.
(Kor J Dermatol 1996(1) : 102~108)
|